Mechanism Action Therapeutic Use Olazanpine Ariprpazole Treatment Schizophrenia Biology Essay Essay Example

Mechanism Action Therapeutic Use Olazanpine Ariprpazole Treatment Schizophrenia Biology Essay Essay In pharmacological medicine, drug is a substance used for the bar, diagnosing, remedy and intervention of disease and for the alleviation of symptoms. It could besides heighten physical or mental wellbeing. There are many mental upsets, a province in which an person s mental orientation is disrupted.A Examples of mental upsets include ; A Acute passion, bipolar, schizophrenic disorder, depression, For this peculiar essay I will be speaking about schizophrenic disorder, its symptoms, proposed aetiology and illustrations of the 2nd coevals drug therapies being used to pull off the status. We will write a custom essay sample on Mechanism Action Therapeutic Use Olazanpine Ariprpazole Treatment Schizophrenia Biology Essay specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Mechanism Action Therapeutic Use Olazanpine Ariprpazole Treatment Schizophrenia Biology Essay specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Mechanism Action Therapeutic Use Olazanpine Ariprpazole Treatment Schizophrenia Biology Essay specifically for you FOR ONLY $16.38 $13.9/page Hire Writer Schizophrenia is a aggregation of symptoms characterised by idea upsets reflecting a interruption between the cognitive and emotional sides of one s personalityA ( Kathryn L. McCance, 2010 ) .A Schizophrenia is classified into positive and negative symptoms utilizing two systems, viz. ; ICD-10 and DSM-IV ( Horton, Schizophrenia, 2011 ) . Positive symptoms which are unnatural experiences non experienced by other people include Hallucination: Described as a perceptual experience experienced in absence of an external stimulation and characterized largely as auditory with patients proposing that they hear voices speaking to them, about them, commanding them, noticing or an reverberation of their ideas Delusion: False belief that they are under the control of an external influence or their ideas are known to other people i.e. paranoia of the wireless or Television FORMAL THOUGHT DISORDER: A upset of conceptual thought reflecting trouble to understand address and rapid displacement from a subject of capable to another i.e. deficiency of consciousness. New words are besides invented ( neologies ) A ( Horton, Schizophrenia, 2011, pp. 1-2 ) Negative symptoms are normal experiences which are non experienced by schizophrenic patients which include ; SOCIAL WITHDRAWAL/ANHEDONIA: proposing they isolate themselves from the universe LACK OF MOTIVATION: deficiency of involvement in things that antecedently interested them Blunted Consequence: Inability to respond usually to emotional stimulation e.g. when informed of the decease of person they laugh alternatively of sympathising A INSIGHT: schizophrenic disorder patients do non belief anything is incorrect with them or the demand for intervention Nether Activity: Do less and speak less than usually COGNETIVE Deficits: Deficits in attending, memory and job resolution ( Horton, Schizophrenia, 2011, p. 2 ) Epidemiology: An incidence rate of 25 per 100,000 per twelvemonth with Life risk 1 % , common in both sexes but onset earlier in work forces [ average age 28years ] whilst adult females [ 32years ] , common in lower socio-economic groups and urban countries ( Horton, Schizophrenia, 2011, p. 2 ) . Familial epidemiologic surveies indicate it is a heritable upset. Lifetime event hazard indicates 8-10 % for siblings with schizophrenic disorder, one parent with schizophrenia 12-15 % whist with both parents ~40 % . In monozygotic twins the harmony rate was 60 % compared to 10 % in dizygoticA twins and Adoption surveies illustrate that cistrons are more critical compared to environment ( Horton, Schizophrenia, 2011, p. 4 ) . However, it differs from simple familial and Mendelian upsets because it involved several cistrons located on different chromosomesA ( Kathryn L. McCance, 2010 ) .A Therefore, no individual cistron has a major consequence but they include 8p, 13q and 22q ( Horton, Schizophrenia, 2011, p. 4 ) . Pathological surveies have observed the undermentioned grounds in the encephalon of schizophrenic patients and they include hypertrophied ventricles ( ~ 40 % ) , reduced encephalon weight ( ~ 30 % ) , reduced cortical Grey affair ( ~ 4 % ) , unnatural bunch of neurones in the cerebral mantle, little cell organic structures and decreased basal dendrites ( Horton, Schizophrenia, 2011, p. 4 ) . CHEMICAL/ NEUROTRANSMITTER THEORY A DOPAMINE THEORY: Hypothesized as due to over activity of Dopastat in the mesolimbic-mesocortical tract with cell organic structures in the ventral tegmentum of the mesencephalon which undertakings to the amygdaloid nucleus, nucleus accumben, hippocampus, frontal cingulate and entorhinal composite ( Horton, Schizophrenia, 2011, p. 3 ) ( Kathryn L. McCance A ; subdivision editors, 2010 ) . The grounds is supported by looking at the consequence of pep pill in let go ofing Dopastat from dopaine receptors [ subtyped D1, D2, D3, D4 and D5 ] in the encephalon taking to schizophrenic like symptoms ( Horton, Schizophrenia, 2011, p. 3 ) . However, grounds against based on looking at the CSF concentration of HVA found non to be elevated as expected, no alteration in DA receptors in PET scans of drug-free schizophrenics but studies show that increased Numberss of D2 receptors in station mortem sample were due to drug intervention ( Horton, Schizophrenia, 2011, p. 3 ) . In decision, it is hypothesized that hypodopaminergicA transmittal in the dorsal prefrontal cerebral mantle leads to veto symptoms whilstA hyperdopaminergicA transmittal in theA mesolimbicA tracts such as the temporal lobe, A hippocampal, A Amygdala, nucleusA accumbensA and anterior cingulated cerebral mantle leads to positive symptomsA ( Kathryn L. McCance, 2010 ) .A A Glutamate: Evidences indicate an under activity of glutamate transmittal such as reduced cerebrospinal fluid [ CSF ] glutamate, loss of glutamate nerve cells in median temporal parts, addition in certain types of glutamate receptors to counterbalance for lessening in transmittal, glutamate receptor subtype [ NMDA ] antagonist PCP makes schizophrenic symptoms worse ( Horton, Schizophrenia, 2011, p. 3 ) GABA [ gamma-aminobutyric acid ] : Evidence of decreased GABA transmittal due to dorsal prefrontal cerebral mantle alterations/ hypoactivity such as lessened maps ofA GlutamicA acidA DecarboxylaseA needed in biogenesis of GABA lead to the negative symptomsA ( Kathryn L. McCance, 2010 ) .A 5HT [ 5-hydroxytryptamine ] : Evidence show an addition in 5HT [ 5-hydroxytryptamine ] transmittal ( Horton, Schizophrenia, 2011, p. 4 ) . A Environmental FACTORS: These include malnutrition in gestation, grippe in 1st trimester, winter/spring births, bringing complications, caput perimeter at birth and minor physical changes ( Horton, Schizophrenia, 2011, p. 5 ) TREATMENTSA Antipsychotic drugs besides calledA Major tranquilizers to clasp the nerve cell which are effectual in handling acute psychosis and cut downing the hazard of future psychotic episodes ( MedicineNet, 2011 ) .A OlanzapineA andA AripiprazoleA are both 2ndA coevals atypicalA antipsychoticsA which exert their effects on a scope of neurotransmitter receptors i.e. non selective compared to typical 1st coevals neuroleptic which chiefly block D2 receptors. There is a discriminatory action on the DA mesolimbic/mesocortical tract over a nigro-stratial tract but research in carnal surveies is ill-defined ( Horton, Major Tranquillizers, 2011, p. 4 ) . Atypical major tranquilizers which have comparatively high 5HT2A adhering affinity to D2 receptors produce lower EPS [ exptrapyramidial symptoms and depress negative symptoms. Upon entry into the synaptic infinite, the antipsychotic drug must vie with endogenous Dopastat for the receptor. Therefore, curative concentration needed to barricade 50 % o f Dopastat receptors in the presence of dopaminewill be higher than that needed in its absence ( Philip Seeman, 2004 ) . This falls in conformity with the equation C50 % = Ki A? [ 1+D/D2 high ] , where D is the dopamine concentration in the synaptic infinite whilst D2 high is the dissociation invariable of Dopastat at the high-affinity province of the Dopastat D2 receptor ( Philip Seeman, 2004 ) . ARIPRIPAZOLEA Indication: Relieve positive symptoms related to extra Dopastat and negative symptoms towardsA dopaminergicA hypofunction.A It is given at a day-to-day dose scope of 10-30mg but get downing dosage could be 10 to 15mg per twenty-four hours ( Kaplan, 2008 ) .A Mechanism: A AripiprazoleA is aA quinolinoneA derivative. Partial agonist at Dopastat D2 and 5-HT1A receptors upon entry into the synaptic infinite and as an adversary competes with the endogenous serotoninA at 5-HT2 receptors. Described as a Dopastat system stabilizer, in high degrees of Dopastat will move as an adversary ( Horton, Major Tranquillizers, 2011, p. 5 ) such as the mesolimbic tract but non in parts with normal Dopastat degrees such as nigrostratial and tuberoinfundibular tracts. Therefore, a D2 partial agonist is expected to cut down the positive symptoms of schizophrenic disorder without bring forthing motion upsets or elevated lactogenic hormone degrees. In countries where Dopastat activity is low, will move as an agonist to let go of dopamine nerve cells from suppression. The D2 receptor is coupled to inhibitory G-proteins [ Gi ] , which upon agonist binding, dissociates from the receptor to suppress secondary messengerA signallingA mechanisms taking to farther suppr essions. At 5HT1A receptors, aripiprazole besides acts as a partial agonist, hypothesized to correlate with overall efficaciousness against the symptoms of schizophrenic disorder including depression, anxiousness and negative symptoms ( MJ. , 2000 ) .The counter consequence on 5HT2 receptors are believed to be associated with a low liability for extrapyramidial side effects [ EPS ] and good for alleviating negative symptoms by disinhibiting the Dopastat system in the striate body and prefrontal cerebral mantle ( Horton, Major Tranquillizers, 2011, p. 4 ) . Normally, DA nerve cells in the nigrostriatum and prefrontal cerebral mantle are inhibited by serotonin heteroreceptors but hostility of 5HT2 receptors means the release of Dopastat neurones, lower D2 receptor obstruction. It besides does non bring on weight addition or QT protraction ( Horton, Major Tranquillizers, 2011, p. 5 ) . Pharmacokinetics: High soaking up making peak plasma concentrations after 3 to 5 hours, protein binding is 99 % and its half life is approximately 31 to 146 hours doing it suited for one time day-to-day dosing, clearance is affected by age cut downing greatly in the aged. It is extensively metabolised by Cytochrome P450 3A4 and 2D6 enzymes with active metabolite, dehydroaripiprazole ( Burns, 2004 ) . Side EFFECTS: orthostatic hypotension, increased hazard of ictuss, sedation OLANZAPINEhttp: //www.druglib.com/img/Rx/3232.gif ( Druglib, Zyprex ( Olanzapine ) -Description and Clinical Pharmacology, 2006 ) Indication: A negative and positive symptoms ofA schizophrenia, A acute passion with bipolar upset, agitation and psychotic symptoms in dementedness. It is given at a day-to-day dose scope of 5-20mg ( Burns, 2004 ) . Class of drug: Atypical psychotics, ATC Therapeutic CategoryA N05AH: Diazepines, A oxazepinesA andA thiazepines ( PharmGkB, 2010-2011 ) A A Mechanism: Adversary enters the synaptic infinite and competes with the endogenousA ligandsA to suppress IÂ ±-1 adrenoceptors and 5-HT2C which both mediates their actions by association with G proteins [ Gq/11 ] that activate a phosphatidylinositol- Ca 2nd courier system whilst at 5-HT2A promotes dopamine release ( Druglib, 2007 ) . In the nigrostriatal tract increased DA reduces EPS and tardive dyskinesia ( Yogesh Dwivedi, 2005 ) but in the mesocortical tract, increased DA release may better negative symptoms, that neuroleptic induced shortage syndrome ( Voruganti L, 2004 ) . OlanzapineA does non look to barricade Dopastat within theA tubero-infundibularA piece of land, explicating the lower incidence ofA hyperprolactinemiaA than with typical antipsychotic agents but alternatively blocks 5-HT2A receptors ( Druglib, 2007 ) . As an adversary of D1 Gs-coupled proteins receptor it prevents activation of Adenylyl cyclase and DARPP-32 ( dopamine andA cAMPA regulatedA phosphoproteinA of 32A kD ) .A Dopamine adhering activates the 2nd messengerA camp to trip ProteinA KinaseA A ( PKA ) which phosphorylatesA DARPP proteins atA ThreonineA residue 34A to suppress phosphataseA protein ( PP1 ) leting PKA to hold a longer active life and overall, A enhanceA the nerve cell s sensitiveness to dopamine signalling. In contrast, dopamine adhering to D2 receptors has an opposite consequence: the 2nd messengerA phosphorylatesA DARPPA on Thr75, doing it to move as a proteinA kinaseA inhibitor andA decrease the nerve cell s sensitiveness to signalling. The D2 and D4 receptor are coupled to inhibitory G-proteins, which dissociate from the receptor on agonist binding and inhibit secondary messengerA signallingA mechanisms doing farther signalling suppression ( Greengard, 2011 ) . Antagonist adhering inhibits this procedure, ensu ing in cell depolarisation.A They besides cause Dopastat to cut down DARPP-32A phosphorylation ( Sarah M. Clinton, 2005 ) . A In add-on, it antagonises histamine H1, A MuscarinicA M1 [ mediate their actions through G-protein-Gq/11 [ in some cases Gs and Gi ] .A Therefore, olanzapine can be seen to hold multiple receptors activities. Side EFFECTS: CNS depression which is due to it counter effects on H1 receptors, orthostatic hypotension, automatic tachycardia and rhinal congestion due to alpha1 suppression whilst blurred vision and urine keeping due to M1 suppression, weight addition, increased QT intervals observed in ECG and increased hazard of shot in dementia aged patients ( Horton, Major Tranquillizers, 2011, p. 4 ) Pharmacokinetics: its half life is 20-70 hours, plasma clearance is 12 to 47L/h and its protein binding is 93 % . It is eliminated extensively by first base on balls metamorphosis, with about 40 % of the dose metabolized before making the systemic circulation by enzymes ; Cytochrome P450 2D6 and 1A2 with no active metabolite ( Burns, 2004 ) . Decision Olanzapine and aripiprazole are therapeutically used orally to handle schizophrenic disorder and have different mechanisms of action. Olanzapine is a multireceptor adversary, suppressing M1, H1, IÂ ±-1, D1, D2, D4 and 5-HT2A/2C receptors whilst Aripiprazole is a breakthrough neuroleptic with partial agonist activity on 5-HT1A and D2 receptors leting it to jump its actions and an adversary of 5-HT2 receptors. They are both used to alleviate positive and negative psychotic symptoms presented in schizophrenic disorder and both have a comparatively high 5HT2A adhering affinity to D2 receptors produce lower EPS [ exptrapyramidial symptoms ] and depress negative symptoms. More so, they portion side effects such as orthostatic hypotension, . Therefore, close monitoring of patients is necessary to guarantee they acquire the best out of their interventions with control over their symptoms and possible drug induced side effects. NICE guidelines published 2002, it is recommended that unwritte n untypical antipsychotic drus are considered in the pick of first-line interventions for persons with freshly diagnosed schizophrenic disorder or considered as intervention options for single presently having classical antipsychotic drugs who, despite equal symptom control, are sing unacceptable side effects and for those in backsliding who have been antecedently experienced unsatisfactory direction or unacceptable side effects ( Horton, 2011 ) . hypertext transfer protocol: //books.google.co.uk/books? id=ubG51n2NgfwC A ; pg=PA546 A ; lpg=PA546 A ; dq=aripiprazole+schizophrenia+mechanism A ; source=bl A ; ots=tm_B5jFcxW A ; sig=KkMB7rniRAyPMTbXjK3CQl8xXPA A ; hl=en A ; ei=gfKUTYCoMIeohAfL6rT2CA A ; sa=X A ; oi=book_result A ; ct=result A ; resnum=9 A ; ved=0CFoQ6AEwCDgK # v=onepage A ; q=aripiprazole % 20schizophrenia % 20mechanism A ; f=false hypertext transfer protocol: //books.google.co.uk/books? id=WuA4LsWXXWEC A ; pg=PA510 A ; lpg=PA510 A ; dq=olanzapine+inhibition+of+5HT2+receptors A ; source=bl A ; ots=ijCtcFYFJk A ; sig=IdYjVggzCLVrGihyl435NUPEjKs A ; hl=en A ; ei=3uqZTcjlO9G5hAesy53wCA A ; sa=X A ; oi=book_result A ; ct=result A ; resnum=5 A ; ved=0CCsQ6AEwBDgK # v=onepage A ; q A ; f=false

Among vs. Amongst

Among vs. Amongst Among vs. Amongst Among vs. Amongst By Ali Hale Summary: Among and amongst are interchangeable terms. Among is more common in modern writing. Americans tend to always use among, while in the UK both among and amongst are used. Although we’ve covered the difference between Among/Amongst in another post on Daily Writing Tips (spoiler alert: there isn’t one), you might still be wondering which word would work best in a particular context. One of our readers, Tania Botha, asked: â€Å"When (if ever) must one use â€Å"amongst† – I systematically use â€Å"among† in my own writing and change it when editing other people’s texts, because â€Å"amongst† seems so old-fashioned. Is there a rule?† If you’re American, you may find that you pretty much never hear â€Å"amongst† – in the UK, where I live, it’s a little more common. (I often heard it in school from teachers instructing us to â€Å"talk amongst yourselves† while they prepared the next bit of the lesson). To answer Tania’s question: there’s no situation where you must use the word â€Å"amongst†, but there are contexts in which it might make sense to use it. If you’re writing a medieval fantasy story, or a piece of historical fiction, â€Å"amongst† could fit well with your tone. For instance: As Tarquin stood amongst the great trees of the ancient forest In the depths of the castle, amongst the detritus of the feast But if you’re writing a news or feature article, or a piece of modern fiction, â€Å"among† is probably a better fit. For instance: â€Å"Australia’s cheap, dirty petrol ranks among the worst of the OECD nations† (The Guardian) â€Å"Six hotels in Llandudno have been named among the best in the UK.† (BBC News) So yes,  amongst  can seem old-fashioned – but it’s still grammatically correct as an alternative to  among. It’s up to you to select which you prefer: if you’re British or Canadian, â€Å"amongst† is unlikely to stand out as especially unusual; if you’re American, it’s almost certainly going to seem oddly old-fashioned unless you’re using it in an appropriate context. Examples of â€Å"Amongst† and â€Å"Among† in Literature In 19th century literature, there are plenty of examples of the use of the word â€Å"amongst† – both from British writers and American writers. Here are a few examples from Jane Eyre, by the English writer Charlotte Bronte. â€Å"Amongst† appears quite frequently: â€Å"I heard a wild wind rushing amongst† â€Å"Flowers peeped out amongst the leaves; snow-drops, crocuses, purple auriculas, and golden-eyed pansies.† â€Å"I lingered till the sun went down amongst the trees, and sank crimson and clear behind them.† But â€Å"among† is also used fairly often: â€Å"She peered at me over her spectacles, and then she opened a drawer and fumbled among its contents for a long time, so long that my hopes began to falter.† â€Å"The company all stared at me as I passed straight among† â€Å"I trode on an edging of turf that the crackle of the pebbly gravel might not betray me: he was standing among the beds at a yard or two distant from where I had to pass; the moth apparently engaged him.† American writers used â€Å"amongst†, too. In Huckleberry Finn, Mark Twain uses it frequently: â€Å"Pretty soon I heard a twig snap down in the dark amongst the trees- something was a stirring.† â€Å"Tom poked about amongst the passages, and pretty soon ducked under a wall where you wouldn’t a noticed that there was a hole.† â€Å"My heart jumped up amongst my lungs.† Again, you’ll also find â€Å"among† being used (though surprisingly infrequently – there are only two instances of it in the whole novel, compared with 37 of â€Å"amongst): â€Å"I struck for the light, but as soon as he turned the corner I went back and got into my skiff and bailed her out, and then pulled up shore in the easy water about six hundred yards, and tucked myself in among some woodboats; for I couldn’t rest easy till I could see the ferryboat start.† â€Å"Then I slipped down to the ground and crawled in among the trees, and, sure enough, there was Tom Sawyer waiting for me.† Ultimately, then, it’s entirely up to you whether you use â€Å"among† or â€Å"amongst†. If, like Tania, you’re editing someone else’s work, you might want to draw their attention to the fact that both words mean exactly the same thing – but that â€Å"amongst† can sound old-fashioned (particularly to American readers). Otherwise – choose whichever word best suits your context and, perhaps, the rhythm and cadence of your sentence. Among vs Amongst Quiz For each of the following sentences and contexts, choose whether among or amongst would be a better fit. 1. Once [among/amongst] the top companies in America, Widgets Inc is now facing bankruptcy. among amongst 2. These tips should help your website rank [among/amongst] the best in the world. amongst among 3. Johannes huddled [among/amongst] the fallen bodies, praying that he wouldnt be seen. among amongst 4. Erica swore. Surely her car keys had to be somewhere [among/amongst] all the clutter on the kitchen counter. among amongst Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Vocabulary category, check our popular posts, or choose a related post below:36 Adjectives Describing Light50 Idioms About Meat and Dairy ProductsOppose and Opposed To

Assignment 3 Research Paper Example | Topics and Well Written Essays - 500 words - 1

Assignment 3 - Research Paper Example The political dimension of immigration comes in when the immigrants’ stay is of a long-term nature. The national government may be required to facilitate their participation in the civil and political life of the nation. This dimension would be in the lines of involving them in discussions regarding policies that may affect their stay in the country (Moses, 2006). The national government may even include them in voting activities. The economic effects come in a variety of ways, both long-term and short-term. Receiving countries may address skill shortages and at the same time, this may result in a burden to public welfare and a decrease in domestic wages (International Labor Office, 2010). The sending countries benefit from receiving remittances from the work performed by their citizens while abroad. If we considered North-North migration patterns in 2013, statistics show a significant number of migrants moving between the Russian Federation and Ukraine. A total of 3.5 million migrants moved to Ukraine from Russia and another 2.9 million people move to the Russian Federation from Ukraine. This massive influx of migrants from these areas may be due to a variety of factors including political instability caused by civil unrest and differences in policies employed to counter these scenarios. In comparison with other migration fields in the south, the migration pattern between these two countries shows the largest mutual flow between any other countries as of 2013 statistics. This pattern is shown evidently by the graph below. Many of these migrants moved in search of a better life, and since the conditions keep on changing in this part of the world, they end up in constant movement from one place to another. They may also move in search of better economic prospects that their country of origin may not have been able to provide. Hence, the migrants’ movement would improve their standards of living. Apart from economic benefits, these migrants may have

Health Ethic Essay Example | Topics and Well Written Essays - 3000 words

Health Ethic - Essay Example 1). In this principle, it takes into account the standardized benchmarks that must be maintained in order to secure the health welfare of patients seeking medical attention. The code basically establishes the kind of relationship shared by patients and their health providers, where the former group is considered inferior compared to superiority exhibited by medically-educated practitioners. Hence, there is a one-sided dependence in such type of association. In current times, there is a shift in the focus of health care from solely treatment provisions to health care promotion and education--there is an integrated transfer of power from health providers to consumers. Where once the medical practitioners hold the sole control on the direction of their clients’ overall care, recent developments account for a more shared responsibility between the two parties involved in health care. Bearing the illustrated changes in mind, there is a general assumption that concepts in medical et hical conduct is not absolute in every situation, including the core ethical principles that govern the medical practice. The paper conducts a case evaluation related to the requested act of withholding the full disclosure medical information by a patient towards biologic relatives, and ethical principles regulating the practitioners’ actions in the performance of such duty. Specifically, this seeks to clarify contradictions in professional limitations of practitioners and extent to which patients can exercise their ethical rights against the moral code of conduct maintained by health providers. Ethical Dilemma: A Case Point Case 1 Mrs M has been having some strange symptoms which have been diagnosed as early symptoms of multiple sclerosis. She realizes she could be unaffected by the disease for some time and so has asked her GP not to tell anyone, even her family. Mr M and their three children are also the GP's patients. The GP is torn by Mrs M's decision because she feels i t would be better if the family knew now rather than finding out later. Mrs M wants to keep this secret because "I don't want them to start treating me differently. I want to look after my family for as long as I can before they start looking after me." Ethics is a complex concept that encompasses more than the networking tenets of what is morally right and wrong. Medical ethics, as identified by Flight (2004), is a definitive set of values that guide the practice of medical practitioners, incorporating a variety of ethical theories to provide basis for conflict resolutions and updates on practical health issues in clinical and community health settings. Basic in almost all types of professional ethics is the presentation of the four core approaches in ethical performance: â€Å"autonomy (freedom to choose), nonmaleficence (do no harm), beneficence (do what is good), justice† (Ashcroft, et al., 2007, p. 4). In one way or another, these principles interact with one another to influence the procedures by which the medical practitioners perform their duties in work environment. In account with the case presented above, a couple of values seemed to be in conflict during the adherence of professional code in ethics. As listed above, autonomy is the exercise of the liberty to choose. In clinical settings, patients are given options to choose among the treatment alternatives available to them. In application, Mrs. M had reserved her right to

Industrialization and the Gilded Age Essay Example | Topics and Well Written Essays - 500 words

Industrialization and the Gilded Age - Essay Example This idea is expressed in the life of Jurgis, and the lives of his family as characterized with constant work, not to live but only to survive. They signify the ones in the working class who are confronted with issues concerning unequal opportunities and labor exploitation. As mentioned by Wasowski, The Jungle serves as Sinclair’s commentary against Industrialization and Capitalism (n.pag.). In the story, the growth of public and private owned businesses creates a gap between employers and employees. The Gilded Age, the period after the Civil War and before the start of World War 1, drives economic and political change. For instance, as the Civil War had made the government more concerned about the people, the American government implemented the tenets of democracy more firmly during the previous years. Additionally, as America had already settled its internal political and civil conflicts, it took concern on economic expansion. The economic expansion in America during the Gilded Age created the working class, widened the gap between workers and employers, and spurred the development of American industrialization. In The Jungle, Sinclair establishes that the Gilded Age is the cause of the unfavorable working condition and unequal opportunities of the working class. Additionally, Sinclair implies that Industrialization and Capitalism can potentially deteriorate the basic American values (equality, independence, democracy). The Gilded Age contributes to the shift in ideals from cooperative alliance to competition among workers. Thus, Sinclair describes the working class in Packington as â€Å"low class and mostly foreign, hanging always on the verge of starvation, and dependent for its opportunities of life upon the whim of men every bit as brutal and unscrupulous as the old-time slave drivers† (116-117). Although slavery is

Identifying Personal Development And Learning Styles Personal Development Essay

Identifying Personal Development And Learning Styles Personal Development Essay It is obvious that as a practicing first-line manager, your own success is more likely if you use your talents (strengths) to their full extent to exploit the opportunities that present themselves to you. Also, its important to understand your weaknesses so that you can manage them out of your daily work activities and thereby also eliminate any threats which may affect your potential to progress. SWOT (Strengths, Weaknesses, Opportunities, Threats) Analysis (Stanford Research Institute 1960-1970) is a useful technique to identify and analyse, in a proactive manner, these four areas. Not only that, but it also provides a good framework for reviewing your own personal development needs and enables you to work on your personal strengths and abilities to distinguish yourself from your peers and hence forward your career My own personal SWOT analysis has been appended to this assignment (see Appendix A). Own Learning Style(s) Identified Honey and Mumford (HM) use the terms activist, reflector, theorist and pragmatist to represent the four key learning styles (or preferences). These correspond to stages in the learning cycle and are based on earlier work by David Kolb (and indeed are used interchangeably by some authors with the terms in the Kolb model). Both models are particularly interesting from the perspective that they offer a way to understand peoples different learning styles but also explain a cycle of experimental learning which can be applied to everyone. The four HM key stages and styles are typically presented at north, east, south and west on a four-stage cyclical flow diagram. This actually expresses a four stage cycle of learning in which having an immediate or concrete experience provides a basis for reviewing/reflecting on the experience. These reflections are assimilated into conclusions from the experience producing implications for action which enables the planning for the next step, i.e. the creation of a new experience. In theory, the learner should visit all four points of the diagram i.e. a cycle of experiencing, reflecting, thinking and acting. They, and their relationship with Kolbs learning styles, are explained in the Table A below: Table A -Comparison of HM Learning stages/styles with Kolb learning style Kolbs Learning Style HM Learning Style/Stage Preferred learning opportunity Personality characteristics of learning style Accomodating Having an Experience/Activists Practical, hands on Here and now; seek challenge and immediate experience; Bored by implementation Diverging Reviewing the experience/ Reflectors Gather information, consider and analyse Stands back; Thoughtful; listens before speaking Assimilating Concluding from the Experience/ Theorists Logical approach, gathers facts to form theories Rational, objective, dismisses subjectivity Converging Planning the next steps /Pragmatists Seeks new concepts, problem solving Likes quick decisions, bored with long discussions Most people naturally prefer a certain single different learning style. Various factors can influence this and Kolb defined 3 stages of a persons development and suggests that the integration of the four different learning styles improves as a person progresses through the development stages. I have completed an HM Learning Style Questionnaire and my preferred learning styles are Theorist and Pragmatist. This means that I have a preference for a concise and logical approach to learning. For me, ideas and concepts are more interesting than people. I do require a good, clear explanation; however, one slight difference to this learning style is that I like to see that the theory can work in a practical situation as well. I enjoy technically related tasks such as gathering and understanding wide-ranging information and trying to organise it in a logical format. In a formal learning situation, my preferences are reading and lectures and having time to consider things. I like to solve problems and make decisions by finding answers to questions. This was not particularly surprising because my job role as an Assurance Specialist involved in auditing actually demands a logical style of approach to deliver work effectively. Furthermore, problem solving is also a key skill for me in advising teams on how to resolve issues with their management processes. Analyse Learning and Development Options and Identify Barriers and Support mechanisms Two learning/development options one for self, one for organisation My personal SWOT analysis identified two development options as follows: To improve my soft skills such as assertiveness, communication and the effectiveness of my decision making. This would help in meeting the needs of the organisation and of the needs of my immediate team. To gain a better understanding of how Environmental Management is applied by Network Rail at a Project level. This would help me to gain an insight as to how I could apply some of the information I learnt on my Institute of Environmental Management (IEMA) course in a practical scenario. I have added both of these onto a Personal Development Plan, which is attached as Appendix C to this assignment. In terms of development opportunity (1), I could make use of the many e-learning tools available via the Network Rail Intranet site as well as obtaining support from my line manager to check my progress as well as him giving me tasks which will help to develop my soft-skills. I could monitor the success of this personal development through regular (once a month) one-to-ones with my line-manager and via my 6-monthly performance reviews. Listening and learning from what has worked well for him in the past would align itself well with the pragmatic approach I prefer to learning. With respect to my own personal development opportunity (2), there is a course offered through Network Rail about Environmental Management within Projects. I have booked a place on this course and intend to follow it up by conducting audits on Environmental Management across Infrastructure Projects as part of the 2010-11 National Core Audit Programme. In this way, I shall be able to speak to Environmental Specialists who apply Environmental Management techniques as part of their daily activities an gain a deeper understanding of what is involved. Identify Barriers to learning and how to overcome them Some potential barriers which could prevent or slow down my progress are time-constraints, distractions and issues with the suitability of e-Learning to my own learning style. These barriers could be overcome by planning a time-out for learning within my weekly schedule and ensuring that I commit to not allowing any work activities to interfere with it. Im unsure as to whether e-learning will complement my learning style because the courses do not present practical situations to apply what has been learnt. However, perhaps regular feedback sessions and suitable tasks set by my line-manager may serve to complement the e-learning courses. Considering the Environmental Management training I have identified, after completing the course, I will need to liaise with the staff drawing up the National Core Audit Programme so that I can be included for the Environmental Section of at least 2 of the audits across the Investment Projects portfolio. The auditing aspect will require me to make careful preparation before visiting the Programme so that I have a full awareness of how they are managing the Environment. This could involve looking at their Environmental Management Plan in detail and compiling a series of relevant questions before I make the visit. Both the training and my IEMA qualification should enable me to do this and carry out the audit effectively. Support mechanisms for self-development I would look to support from my line-manager and team members through the use of formal (1-2-1s) and ad-hoc reviews of my progress. Regular teleconferences or face-to-face meetings with members of the cohort who attended the same Leading and Managing Teams course could also be set up, where we could discuss our own personal progress and problems. These may prove to be extremely beneficial from a learning perspective for all concerned. I would also like to involve the Investment Projects Environment Manager and Environmental Specialists from the Programmes from the perspective of them being there to provide expert advice on technical questions. Two other support mechanisms which suit my learning style are testing and feedback. I am most comfortable with regularly testing my new skill sets as demonstrated with the Environmental training taking what I have learnt and applying it to actual situations in the workplace and obtaining feedback on what I did well and what I should look to improve on next time. This would provide me with the assurance that, not only do the techniques work, but also that I am progressing in the right direction. It would be an invaluable confidence builder both in my abilities and that the learning plan is delivering the desired results. Monitor and Evaluate Self-development One method to monitor and evaluate self-development I would monitor and review my learning using a learning log. This could be used to plan learning activities as milestones on the way to achieving the completed development activity and as a reference to check that milestones are being completed on time (through one-to-ones with the line manager). The log allows the user to focus in on the particular learning areas which are important to him, and to visualise the progress being made. For me, this would apply to areas such as assertiveness, communication skills and Environmental knowledge, for example. The log will allow others, such as team members and the line manager to understand what it is that an individual is trying to achieve and provide assistance and feedback where it is required. In addition, the learning log is a good tool for recording feedback, enabling the noting down of what went well and what could be improved with each learning activity as well as how the approach can be changed next time. Eventually, it should indicate for me, whether soft skills are still a learning area of me or whether I have shown, through practical demonstration, that I have mastered them. An example of a real learning log (extract) is attached as Appendix B to this assignment. For feedback to be effective, the Action Impact Do/Develop/Different model should be applied That is, the person giving the feedback should provide examples of what was done, its impact on the situation, and what should be done differently next time. This would allow the recipient to consider a different approach and modify his behaviour accordingly This is particular relevant to the skills I am trying to develop. Appendix A Personal SWOT Analysis Weaknesses I have a strong compulsive need to do things quickly especially when my to do list is long. Sometimes this has compromised my decision making ability. My need to keep the customer happy can sometimes lead to me acquiescing to his needs rather than defending my own position. I have a tendency to over-analyse what has happened in certain situations (even after I have prepared really well for them) when events have moved on and I can no longer do anything about them. I get a little nervous about presenting to members of the team and to customers. This can mean that these types of Presentation do not engage the audience as much as Id like. Strengths I have good analytical skills. I enjoy looking through data to determine conclusions and action planning to improve the current situation. I am very conscientious and deliver all work to the very best of my ability. I pride myself in organising my work so that it is always delivered on time. I go out of my way to satisfy or delight the customer. I am completely committed to the success of the team that I work for and creating a good impression of what we do to our customers/stakeholders. I have worked in Assurance/Quality related roles for over 20 years and have experience in most aspects of these functions. My job means a lot to me, I take it very seriously. Threats Potential future reorganisations meaning redundancy. Assurance becomes no longer a priority for the company. Perceptions and criticisms by customers and own team. 2012 move to Milton Keynes and the feasibility of commuting there on a daily basis. My current need for a lot of support from my line manager could be perceived that I no longer feel comfortable in taking decisions without someones help. Opportunities We are currently developing a customer feedback questionnaire which we will get our main stakeholders to complete. The output from this should help us to determine the areas we need to improve on going forward We have a lessons-learnt process and are always looking to improve the auditing process. That I take the knowledge Ive accumulated from the Leading and Managing Teams course and consistently look back on it and apply it to my day job. That I continue to work with my main customers to build a reputation with them so we are clear about what we expect from each other and that this leads to a positive working relationship which delivers results. Appendix B Learning Log (extract only) Date From Date to Activity What went well? What didnt go well? What you will do differently next time Nov. 09 Dec. 09 E-Learning Course Assertiveness The course was completed and all of the intermediate assessments passed There was no interaction element to the course how do you know it works in practice? This needs to be incorporated into 1-2-1 meetings to get feedback from line-management on how I am progressing/if this is still a development area for me. 23/11/09 23/11/09 Opening Meeting CrossRail audit All of the points on the agenda were covered Organisation was poor jumped from one topic to the next and then back again in a haphazard fashion Improve preparation plan out exactly which points to cover and at which times 12/01/10 12/01/10 Closing Meeting CrossRail audit Far more relaxed, bought the correct key people to the meeting deflected difficult questions to them at the right time Nothing to report do it the same next time. Carry this lesson forward for the 2010-11 National Core Audit Plan (NCAP). 15/02/2010 15/02/2010 One-day training session Environmental Management on Projects A good internal training session about how to apply the requirements of the Network Rail Environmental Management Handbook (Guide to Railway Projects Delivery Manual 04) on Projects Additional time to built into the course to go through some of the worked-examples in further detail. This knowledge needs to be applied in future as part of the 2010-11 NCAP audit of Environmental Management. Opportunity to be sought to take part in this section of the audit. Appendix C PERSONAL DEVELOPMENT PLAN Preferred Learning Style/s Pragmatist/Theorist What do I want or need to develop? What actions / development will I do to achieve this? How will success be determined? Target dates for review and completion 1.My soft skills; e.g. Assertiveness, Listening, Coaching abilities E-Learning. Mentoring from my Line Manager. Experiences in my role. 1-2-1s; performance review meetings; improved confidence April 2010 (end of year review) 2. Understand Environmental Management on Network Rail Projects Network Rail course Environmental Management within Network Rail assisting National Core Audit Programme with Environmental auditing aspects. I will be able to carry out effective Environmental Audits of Network Rail Programme/Projects as determined both by Environmental Specialists on the Programmes and by the Investment Project Environment Manager. October 2010 and April 2011

The National Climate Change Technology Initiative :: Environmental Policy Politics

The National Climate Change Technology Initiative (NCCTI) On June 11, 2001, in combination with his creation of the U.S Climate Research Initiative, President Bush stated that the United States is a world leader in technology and innovation and new technologies can offer a great advance towards climate change. As a result, Bush created a complement to the Climate Change Research Initiative (CCRI), called the National Climate Change Technology Initiative (NCCTI). The goal of NCCTI was to make the U.S a stronger leader of climate change-related technology research and development by improving research and development investments across U.S. agencies and by focusing the Federal R&D portfolio on Bush's climate change goal, both near and long term. NCCTI adds on to an extensive foundation of ongoing activities in R&D of climate change-related technologies. The President said on June 11, 2001: "We're creating the National Climate Change Technology Initiative to strengthen research at universities and national labs, to enhance partnerships in applied research, to develop improved technology for measuring and monitoring gross and net greenhouse gas emissions, and to fund demonstration projects for cutting-edge technologies, such as bioreactors and fuel cells."(5) Potential impacts of technology on a global scale are relatively long-term, the NCCTI is guided over this by the climate change goals of the United Nations Framework Convention on Climate Change of 1992 (Kyoto Protocol), ratified by the United States and more than 170 other countries (5) (3). The UNFCCC calls for the "... stabilization of greenhouse gas concentrations in Earth's atmosphere at a level that would prevent dangerous anthropogenic interference with the climate system."(5) In order to achieve this long-term goal, net emissions of greenhouse gases on a global scale must ultimately approach levels that are lower than they are today. (1) Current activities of the NCCTI include a thorough and continuing review of all climate change technology-related research and development programs, with focus on improving the integration of supporting basic research activities. The NCCTI interagency working group is developing criteria to identify high-priority programs that may have the largest potential impact in the long term for reducing, avoiding, or sequestering greenhouse gas emissions.(5)(4) NCCTI also includes a proposal to fund a unique competitive solicitation program, in which technology research ideas will be funded on the basis of their potential to reduce, avoid, or sequester greenhouse gas emissions.

Cognitive Impairment Screening in Senior Citizens

I told you three times yesterday you had a doctor's appointment and that I was going to come pick you up. † Judy shuffled back to the kitchen to double check her calendar, followed by her daughter. Both of them stopped in their tracks, taking in the ransacked kitchen. Her daughter asked what had happened in here, but Judy couldn't answer her. She was beside herself. Who could have possibly broken into her home and torn her kitchen apart? Dementia has reared its ugly head. Phil Just wanted to pay for his Reuben. He had been out and about running errands and was very hungry.The young man behind the counter had tried to charge his debit card more than a few times, but to no avail the card was denied each time. Phil began to recant his day to himself. Then It dawned on him, he had closed his bank account only a few hours before. Phil was getting ready to move down to Texas with his son due to his recent diagnosis of Alchemist's. Phil was a regular at the dell and the manager gave h im the Reuben on the house. â€Å"One of the worse things about this rotten disease Is losing the ability of taking care of myself† (Phil Rolled, 2010). Just frustrating for me, not to remember what I need to do to Just feel like I still can live and take care of myself. † This Is a common frustration expressed by those suffering diseases like dementia and Dementia is a costly disease; for the five million people like Phil and Judy living tit the disease in the United States, for Phil and Judy family, and for the government. Earlier detection and intervention of dementia would provide Phil and Judy the time to plan for the future and get the utmost benefit from available treatments.Earlier detection and intervention of the disease would lessen the future financial burden on health care. Cognitive impairment screening would ascertain if early intervention is needed. Cognitive impairment screening in senior citizens must become practice. Dementia is used as an umbrella te rm; describing a wide range of symptoms that include a progressive decline in mental ability severe enough to interfere with daily life. Dementia slowly robs Phil and Judy of their memories. At first, they experience problems with their short-term memory such as remembering an appointment.As time passes, the disease steals more and more of the brain. Phil and Judy eventually will not be able to respond to their environment, nor will they be able to express when they are in pain, or hungry, or thirsty, or when they have to go to the bathroom. A true diagnosis is rare, because dementia affects everyone differently. There is no ere. Dementia is considered an old person's disease. It's normal to forget where you left your keys when you're 65 years old or to forget where you parked the car. Contrary to popular belief, dementia is not a normal part of aging.Alchemist's is the most common type of dementia, but there are many other types. One of the biggest risk factors in developing dement ia is a person's age. Unless someone has stumbled onto the fountain of youth, no one can change or hide from their age. Persons age 65 and older have a greater risk of suffering from dementia. Every five years those Hansen double, so by the time Judy is 85 years old – her chance is nearly 50 percent. Today, there is an estimated five million people living with a dementia related disease in the United States. (What is Dementia, n. D. With the first wave of Baby Boomers already at age 68, the cost of dementia in 40 years is expected to exceed $1. 2 trillion (Alchemist's Fact and Figures, n. D. ). In 2010, the worldwide costs associated with dementia equaled one percent of global GAP. One percent doesn't seem like much on a global scale. However, if dementia care was a company; Dementia Inc. Loud be considered the world's largest by annual revenue. (GE Healthcare, 2014) The Alchemist's Association predicts the total number of dementia-related cases in the United States will reac h 14 million in the year 2050.Our healthcare system and the Medicare program are already strained. As the Baby Boomers get older, are we going to be able to weather the suffocating financial squeeze this disease is going to create? Phial's family is lucky to catch the disease before it has progressed too far, his son will be able to take care of him at home until the disease progresses further. The average cost for caring for someone at home is $12,500 per year. As the disease robs Phil of more brain function, more skilled care is required. Families can be billed anywhere from $42,000 to $72,000 per year.Victims and their families can easily deplete their savings on medical care and then turn to Medicare/Medicaid and tax payers to help with the remaining costs. Judy may have already passed the opportune time to either stay at home with her daughter or have in-home care and ultimately needs to go live either in an assisted living or nursing themselves for the price of skilled care. S enator Tom Harkin stated â€Å"The only way we are truly going to save Medicare from bankruptcy when the baby boomers retire is to reduce the length and incidence of expensive illnesses like Alchemist's. Harkin, Chairman of the Appropriations Subcommittee on Labor, Health and Human Services, and Education, and Related Agencies recently held a hearing in February of 2014 to inspect the financial impact of Alchemist's in America (Bethlehem, 1998). But how do we reduce the length of disease that has a difficult diagnosis and no cure in the foreseeable future? We need to be looking at intervention opportunities. All things considered, some will argue that dementia-related diseases are only a small part of a much bigger problem, dismissing the idea that the disease could bankrupt Medicare. Projections of the frequency of a disease 30 years from now should be taken with a grain of salt,† said Gail Wiliness, chairman of the federal Physician Payment Review Commission (Bethlehem, 199 8). â€Å"We don't know how the frequency of other disease will rise or fall, and how that will affect longevity. † She went on to commend the fact that medical research has allowed people to live longer lives and improve quality of fife. However, she questioned whether the research has saved us any money.Wiliness almost sounds like she is agreeing with another rarely expressed view that concludes if we devote more money and effort into finding a cure for dementia; that will only prolong the life of the elderly by a few more years. Crudely put, if you don't die of complications from dementia, you'll still die of something else. Understandably, we can't avoid death. That is an inevitable fact of life. If we as a community could act early, if we as a community could provide intervention, what kind of standard would e set for the rest of the nation?Earlier detection of dementia could provide earlier intervention, delay the impact of the disease, and prevent significant health ev ents in the future. Does that process sound familiar? In 2013, The United States Preventive Services Task Force recommends women get a mammogram every 2 years starting at age 50 to keep proactive about breast cancer (Mammograms Fact Sheet). Furthermore, the same task force recommends oscilloscopes in adults beginning at age 50 and continuing until age 75 (at different intervals depending on family history) o prevent colon cancer.Curious, I went to the U. S. Preventive Services Task Force website on Recommendations for Adults. I found preventative information on 19 different cancers and 11 different types of heart disease. I found nothing on dementia or Alchemist's. Nothing. Alchemist's disease is the 6th leading cause of death in the United States (Leading Causes of Death, 2011). The top five include heart disease, cancer, chronic lower respiratory disease, and stroke. All five of those diseases all have preventative measures and are routinely screened for in our annual heck-ups wit h our doctors.What needs to be addressed though is why there is more prevalence on detecting cancers and heart disease? John Morris, professor of neurology and co-director of the Alchemist's disease research center at Washington University's School of Medicine, believes we should find a way to distinguish between the normal aging process and early dementia and build more interest (Bethlehem, 1998). This is where a cognitive assessment could help bridge that gap. A cognitive assessment is an examination that is used to determine someone's level of cognitive function.A group of 2,719 elderly residents in Almagest County, Minnesota were 2014). The doctors conducting the case knew from earlier studies that elderly residents would sometimes have a cognitive assessment that indicated some impairment, but when examined again later, the impairment had lessened or completely gone away. During this trial, 40% of people with a mild cognitive impairment reverted back to a more normal state. At the end of the study, the doctors found that 65% of those â€Å"reverts† went on to develop dementia (Berliner, 2014).While this study shows that not everyone who has cognitive impairments may o on to develop dementia, the doctors were certainly more aware of any changes. Unfortunately, there isn't one type of assessment test that is better than the others. However, the Alchemist's Association website has recommended several cognitive assessment tools that can be performed in less that or around five minutes in a primary care or community setting. Not only are there patient assessment tools, there are informant tools for family members and close friends to use as well. Utilizing these assessments Just once isn't going to do the trick.Then again, imagine f the U. S. Preventative Services Task Force recommended a cognitive assessment screening every two-three years starting at age 65. Cognitive impairment screening must become practice for senior citizens. The assessments may n ot garner conclusive data, but over time we will be able to create a clearer picture as to how dementia slowly progresses. From that picture, we will develop earlier intervention techniques to help ease not only the financial strain on Phil and Judy and their families, but ease the frustration felt by dementia's victims.

Strategy and Tactics of the Hundred Years War

Strategy and Tactics of the Hundred Years War As it was fought for longer than a hundred years, it’s no surprise that the strategy and tactics used by all sides in the Hundred Years War evolved over time, creating two very different eras. What we see is an early English tactic proving successful, before technology and warfare changed to a French one becoming dominant. In addition, the aims of the English may have stayed focused on the French throne, but the strategy to achieve this was starkly different under two great monarchs. Early English Strategy: Slaughter When Edward III led his first raids into France, he was not aiming to take and hold a series of strongpoints and regions. Instead the English led raid after raid called a ‘chevauchà ©e’. These were missions of pure murder, designed to devastate a region by killing crops, animals, people and destroying buildings, windmills and other structures. Churches and people were plundered then put to the sword and fire. Huge numbers died as a result, and wide areas became depopulated. The aim was to cause such damage that the French wouldn’t have as many resources, and would be forced to negotiate or give battle to stop things. The English did take important sites in Edward’s era, such as Calais, and small lords fought a constant battle against rivals for land, but the strategy of Edward III and leading nobles was dominated by chevauchà ©es. Early French Strategy King Philip VI of France first decided to refuse giving a pitched battle, and allow Edward and his followers to roam, and this caused Edward’s first ‘chevauchà ©e’s to cause great damage, but to drain the English coffers and be declared failures. However, the pressure the English were exerting led to Philip changing strategy to engage Edward and crush him, a strategy his son John followed, and this led to the battles of Crà ©cy and Poitiers were larger French forces were destroyed, John even being captured. When Charles V went back to avoiding battles – a situation his now decimated aristocracy agreed with – Edward went back to wasting money on increasingly unpopular campaigns which led to no titanic victory. Indeed, the Great Chevauchà ©e of 1373 marked an end to large scale raiding for morale. Later English and French Strategy: Conquest When Henry V fired the Hundred Years War back into life, he took a totally different approach to Edward III: he came to conquer towns and fortresses, and slowly take France into his possession. Yes, this led to a great battle at Agincourt when the French stood and were defeated, but in general the tone of the war became siege after siege, continuous progress. The French tactics adapted to fit: they still generally avoided great battles, but had to counter siege to take the land back. Battles tended to result from contested sieges or as troops moved to or from sieges, not on long raids. As we shall see, the tactics affected the victories. Tactics The Hundred Years War began with two large English victories stemming from tactical innovations: they tried to take defensive positions and field lines of archers and dismounted men at arms. They had longbows, which could shoot faster and farther than the French, and many more archers than armoured infantry. At Crà ©cy the French tried their old tactics of cavalry charge after cavalry charge and were cut to pieces. They tried to adapt, such as at Poitiers when the whole French force dismounted, but the English archer proved a battle winning weapon, even to Agincourt when a new generation of Frenchman had forgotten earlier lessons.If the English won key battles earlier in the war with archers, the strategy turned against them. As the Hundred Years War developed into a long series of sieges, so archers became less useful, and another innovation came to dominate: artillery, which could give you benefits in a siege and against packed infantry. Now it was the French who came to the fore, because they had better artillery, and they were in the tactical ascendance and matched the demands of the new strategy, and they won the war.

DBQ on the Causes of the French Revolution Essay Example

DBQ on the Causes of the French Revolution Essay Example DBQ on the Causes of the French Revolution Essay DBQ on the Causes of the French Revolution Essay Change is feared. It is frequently heard that people merely fear alteration. Sometimes. nevertheless. thats non ever true. Some claim that they fear the alteration. when they simply like the manner things are and refuse to see things in another manner. When discontent spreads throughout the bulk of the population of French. a forced radical war is the lone manner to convert that alteration is necessary. Three chief things contributed to this desire for alteration. and those include revenue enhancements excessively unbearable to pay and last. thoughts promoting alteration that were inspired by the Enlightenment. and the success of the American Revolution. Before the Revolution. France was divided socially in a construction known as the Old Regime. It consisted of three estates. The First Estate was the clergy. who owned 10 per centum of the land but comprised of merely one per centum of the population. The Second Estate. with aristocracy. included two per centum of the population but owned 35 per centum of the land. The largest was the Third Estate. which was made up of the in-between category. provincials. and metropolis workers. owned merely 55 per centum of the land but made up 97 per centum of the population ( Doc. 2 ) . The Third Estate was taxed in utmost proportions so much so that staff of life. which was a necessity and the base of all repasts. became really hard to pay and obtain. It was going progressively hard to last on so small ( Doc 1 ) . However. the first two Estates lived easy with no revenue enhancements. Even the middle class. the in-between category. became every bit affluent as the predating Estate. but because of where they were born. they were still burdened by revenue enhancements. This led to restlessness in the Third Estate. Since they comprised most of France. they joined together and planned a rebellion. However. it is impossible to ramp in and anticipate changes without a program. To fix for this. the thoughts from the Enlightenment helped to change the way France was taking. After newly coming from this new age of thought and analytical surveies. the in-between category could easy utilize the thoughts of authorities. economic system. and societal construction to command a fluctuation ( Doc. 4 ) . One chief subscriber to the Enlightenment was Monsieur Rousseau. He believed in the will of the bulk ; that is. the majority of a group determines the concluding result. This appealed to the Third Estate because they did do up the greater portion of France. It was a good theory to them. Another subscriber to the Enlightenment was John Locke. He believed that all people are born with three natural rights: life. autonomy. and belongings. No affair what category a individual was born into. these rights should non be taken off. If the regulating system abuses these rights. so the people have a right to subvert the authorities. Halfway across the Earth. another revolution was taken antecedently. That was the one of settlements. known as the American Revolution. The settlements at that place. excessively. were upset by the heavy load of revenue enhancements and their deficiency of say in the affair. This applied to the Gallic Third Estate. every bit good. After the underdogs of America eventually pulled from behind and conquered the almighty Great Britain. this led to inspiration of another Revolution ( Doc. 5 ) . That flicker was used as a motivational tool to subvert the lumbering French governmental system. The win in the American settlements encouraged the Gallic to make the same. The first two Estates failed to see the job with the affair. and they were non at all pleased to be overshadowed by their ain people. With the disgruntled First and Second Estates strained to contend one time once more. this clip against their ain people. alteration was brewing. and it could be seen in the eyes of all. Armed with the choler against the heavy. intolerable revenue enhancements. the glare of the enlightened thoughts. and the assurance from the American Revolution. the Third Estate prepared to conflict and seek the transmutation they so urgently desired.

The House Washing Machine for Disabled and Normal People Essay

The House Washing Machine for Disabled and Normal People - Essay Example Introduction The process of learning how to carry out some basic health care activities starts from childhood to the adolescent period. Such basic activities includes tasks like washing dishes and clothes, simple meal preparations such as making sandwiches and community activities such as catching a bus. During the late stages of adolescence and the early stages of adulthood, there is always some expectation that an individual should become more independent when handling the daily living activities either at the home level of at the community level. People who are mature and have never had the basic skills of homecare and household activities are able to do so with some appropriate support, thus making them achieve their own independence. Age and disability should not be an excuse to make one unable to handle basic household activities but with the availability of possible alternatives, everything becomes easier. Market Analysis It has now become a common objective for the adults that are living at home to develop the ability of handling things on their own whether disabled or in normal state. In as much as one might be receiving enough support from a family member or a caretaker, having a machine that will help this group of people will make every task much easier. Many people having a problem with washing of both clothes and house cleaning duties may be able to handle this if given an opportunity to make things easier. Developing the ability to handle household chores has the capacity of leading one to achieve independence and that an individual will not be a burden to other members in the house. It is of great importance to provide your child with the practice the daily leaving skills, even if such tasks take longer time and require even more effort. Before coming up with the right product for this population, there is need to look and study the market. An analysis on market shows that at the elderly and children with disabilities are the ones that require more help in handling household duties. In the status now, there is an approximate of around 19 million working-age people with disabilities. This market analysis intends to breach the gap on the housing status of working-age people with disabilities. The reason for focusing on this population is that it represents the large and overgrowing segment that relies heavily on the state and the federal government’s programs. For instance, the government spends nearly $360 billion or an average of $19000 per person on programs relating to elderly people and children with disabilities (Livermore et al., 2010). This gives the government a burden at settling these bills and with special machinery in the market to assist this population; it makes it an open opportunity for the government to relieve itself o extra costs and instead invest the cash on the machinery that will make the lives of this population easier. This will be an open business opportunity for the company that will be manufacturing these machines and at the same time offering a solution to the people with disabilities. The data presented by many other research firms indicates the relationship between housing characteristics and the people with disabilities. Periodic reports provides an estimate that there is worst-case housing needs, and the most recent report indicates that approximately 1 million nonelderly households that have disabled members have the worst-case needs, making a total of approximately 36-percent rate of the total population that deserves to better care facilities. This same research have provided data on the economic backgrounds of the population majorly affected with disability problems and has been able to determine that majority of this population are from poor backgrounds. This implies that there is need to make affordable equipments for the generation so that many can have the opportunity to access them. Any company that is aiming to produce the housing washing

MARRIAGE Essay Example | Topics and Well Written Essays - 1250 words

MARRIAGE - Essay Example One can also designate other equally important topics of the consideration of marriage, namely marriage as "as a reflection of the life of the Trinity," "domestic Church," and "a vocation." (â€Å"Marriage,† 35, 38, 43). Finally, Christian theology considers the themes of "growth in Christian marriage," "growth in the virtues toward perfection, "and a" marriage fulfilled in the Kingdom of God" (â€Å"Marriage,† 45, 47, 52, 56)Ã'Ž As indicated above, the Christian church in the face of Catholic priests based is on the belief that marriage is not only a creation of the people as a union between men and women. Marriage is primarily a gift of God, which is regarded by God as free from original sin. The sanctity of marriage is determined by the union between a man and a woman, who are created in the image and likeness of God. In addition, the basic meaning of marriage is that it "has two fundamental ends or purposes towards which it is oriented, namely, the good of the spouses as well as the procreation of children" ("Marriage," 11). A man and a woman are united in marriage not only as spiritual beings, but also as material beings. They become one flesh. United by love, men and women live for each other. Each of them thinks about his/her partner as the meaning of life that causes them to be ready to sacrifice everything for the sake of him/her. This unity finds its logical continuation in children. Having childre n is an amazing act that sanctifies the union between a man and a woman and makes it adequate to Gods plan. Only the appearance of children makes a marriage a true union between a man and a woman. According to the second theme, the Christian understanding of earthly marriage involves its comparison with the Trinity. Earthly marriage is a union between a man, a woman, and their children. This unity is based on love and devotion that make all members of the family inextricably linked. The basic meaning of marriage is